Base Editing: A Strong Contender in Cell and Gene Therapy


Base editors, DNA double-strand break (DSB)-independent genome modification agents, have been recognized alongside prime editors as key technologies to watch this year,1 and advances to date have been encouraging. Although these technologies have yet to enter the clinic, the first candidate therapy received investigational new drug approval from the U.S. Food and Drug Administration in 2021—less […]

Enzyme that Promotes Diet-Induced Obesity Could Point to Inhibitor Therapy


High-fat diet (HFD) feeding in mice promotes induction of aldose reductase (AR) activity, expression, and senescence of adipocytes in subcutaneous adipose tissue (scAT), according to a new study in Obesity. The researchers, headed by a New York University Grossman School of Medicine team, suggest that their findings could point to potential new strategies for treating obesity. […]

Lab-made sperm’ fertility hope


Scientists have proved for the first time that sperm grown from embryonic stem cells can be used to produce offspring. The discovery in mice could ultimately help couples affected by male fertility problems to conceive. And by understanding embryo developmental processes better, a host of other diseases might be treated using stem cells, they say. […]

ISCA International Summerschool (COLOGNE, JULY 8-10, 2019)

Applying Stem Cells in Personalized Medicine Download Brochure Recent development in stem cell technologies revealed that human stem cell can be used to test how diseased cells respond to drugs. This success highlights a pathway toward faster, cheaper and more difficult drug development for some genetic illnesses, as well as the ability to pre-test a […]